Micro encapsulation of Naproxen By Complex Coacervation and Aqueous Colloid Dispersion Part ( 1 )

Micro encapsulation of Naproxen By Complex Coacervation and Aqueous Colloid Dispersion Part ( 1 )

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Naproxen is a non steroidal Balboa hats anti inflammatory and antipyretic drug which has local irritation effect on the stomach, and unpleasant taste, besides bad flowability and light sensitivity.The drug was prepared as microcapsules by complex coacervation method using acacia-gelatin coating materials , and aqueous colloid polymer dispersion method ( ACPD ), using ethyl cellulose and sodium alginate coating materials.The results indicated that microcapsules prepared by 2:1 core:wall ratio is the best for both methods, with an average encapsulation efficiency (75%) and avarege TV Remote yield (90%).

Moreover the drug release was affected mainly by core : ratio ,pH enviroment and method of microencapsulation.Key words: Naproxen,Microcapsule , Aqueaus colloid polymer dispersion.